"...Liftoff of Space Shuttle Endeavour, going where East and West do meet at the International Space Station!" NASA reports:

Endeavour Lifts Off!

March 11, 2008 - 2:28 a.m. EDT
Brilliantly lighting up the dark sky, space shuttle Endeavour roared off the launch pad carrying the STS-123 crew, a module of Japan's Kibo laboratory and a Canadian robotic system to begin the 25th mission to the International Space Station.

Space Shuttle and Crew Space Station Bound Endeavour lifted off of NASA Kennedy Space Center’s Launch Pad 39A right on time for a flawless beginning to the STS-123 mission. With engines and boosters roaring the space shuttle headed spaceward as it brilliantly lit up the dark sky over Florida's east coast.

Check the links at right for play-by-play and NASA TV.